Sports News
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| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Arantxa Rus | Win | 6-2, 6-2 |
| Third Round | Victoria Azarenka | Loss | 5-7, 4-6 |
| J&T Banka Ostrava Open 2021 | ||
| Surface: Hard | Date: Sep. 20 - Sep. 26 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anastasia Potapova | Win | 6-1, 6-7 (4-7), 6-3 |
| Quarterfinals | Jil Teichmann | Win | 6-4, 6-4 |
| Semifinals | Anett Kontaveit | Loss | 0-6, 4-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Polona Hercog | Win | 6-1, 6-2 |
| Second Round | Kristyna Pliskova | Win | 7-6 (7-4), 6-2 |
| Third Round | Maria Sakkari | Loss | 4-6, 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Madison Keys | Win | 7-5, 6-4 |
| Second Round | Veronika Kudermetova | Win | 6-2, 6-4 |
| Third Round | Ons Jabeur | Win | 6-1, 6-2 |
| Quarterfinals | Angelique Kerber | Loss | 4-6, 3-3 Retired |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Fiona Ferro | Win | 6-4, 6-4 |
| Third Round | Camila Giorgi | Loss | 4-6, 4-6 |
| Livesport Prague Open | ||
| Surface: Clay | Date: Jul. 12 - Jul. 18 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Rebecca Sramkova | Loss | 6-7 (5-7), 6-3, 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Sloane Stephens | Loss | 3-6, 4-6 |
| Bad Homburg Open | ||
| Surface: Grass | Date: Jun. 20 - Jun. 26 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Katarzyna Piter | Win | 4-6, 6-1, 6-4 |
| Second Round | Ann Li | Win | 6-2, 6-7 (4-7), 6-1 |
| Quarterfinals | Nadia Podoroska | Win | 6-3, 7-6 (12-10) |
| Semifinals | Angelique Kerber | Loss | 6-3, 4-6, 6-7 (3-7) |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Greet Minnen | Win | 6-7 (3-7), 7-6 (7-5), 6-1 |
| Second Round | Elena Vesnina | Loss | Retired |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 16 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Magda Linette | Win | 1-6, 6-0, 6-2 |
| Second Round | Vera Zvonareva | Loss | 4-6, 6-3, 4-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Marie Bouzkova | Win | 6-2, 2-3 Retired |
| Second Round | Angelique Kerber | Win | 6-4, 7-5 |
| Third Round | Veronika Kudermetova | Win | 6-3, 4-6, 6-4 |
| Quarterfinals | Ashleigh Barty | Loss | 1-6, 6-3, 3-6 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 19 - Apr. 25 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Jennifer Brady | Win | 6-4, 6-3 |
| Second Round | Maria Sakkari | Win | 6-3, 3-6, 6-3 |
| Quarterfinals | Elina Svitolina | Loss | 7-6 (7-4), 5-7, 2-6 |
| Volvo Car Open | ||
| Surface: Green Clay | Date: Apr. 5 - Apr. 11 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Storm Sanders | Win | 7-6 (7-4), 6-2 |
| Third Round | Danka Kovinic | Loss | 4-6, 1-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alize Cornet | Win | 6-0, 6-4 |
| Third Round | Johanna Konta | Win | 6-1, 6-2 |
| Fourth Round | Elina Svitolina | Loss | 6-2, 5-7, 5-7 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Mar. 7 - Mar. 13 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jil Teichmann | Loss | 2-6, 4-3 Retired |
| Qatar Total Open 2021 | ||
| Surface: Hard | Date: Mar. 1 - Mar. 6 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anastasia Pavlyuchenkova | Win | 6-1, 6-3 |
| Quarterfinals | Anett Kontaveit | Win | 6-3, 3-6, 6-2 |
| Semifinals | Jessica Pegula | Win | 6-4, 6-4 |
| Final | Garbine Muguruza | Win | 6-2, 6-1 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Greet Minnen | Win | 6-3, 6-4 |
| Second Round | Sorana Cirstea | Loss | 4-6, 6-1, 1-6 |
| Yarra Valley Classic | ||
| Surface: Hard | Date: Jan. 31 - Feb. 6 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Venus Williams | Win | 7-6 (8-6), 7-5 |
| Third Round | Nadia Podoroska | Loss | 7-5, 1-6, 6-7 (7-9) |
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